Monday, 02 February 2015 11:47
Published in IVF Research

In-vitro culture of human embryos with mechanical micro-vibration increases implantation rates

Vladimir Isachenko a,*, Robert Maettner b, Karl Sterzik b, Erwin Strehler b, Rolf Kreinberg a, Katharina Hancke a, Steffen Roth c, Evgenia Isachenko a

a Section of Gynaecological Endocrinology and Reproductive Medicine, University of Ulm, Prittwitzstr. 43, 89075 Ulm, Germany
b Center of Reproductive Medicine, Endokrinologikum Ulm, Praxisklinik Frauenstrasse, Frauenstr. 51, 89073 Ulm, Germany
c Xceltis GmbH, Im Tal 12, 74909 Meckesheim, Germany
* Corresponding author. E-mail address: This email address is being protected from spambots. You need JavaScript enabled to view it. (V Isachenko)


The in-vitro culture of human embryos in a medium subjected to regular short intervals of mechanical agitation leads to increased development rates. This type of treatment tries to mimic conditions in nature whereby oviductal fluid is mechanically agitated by the epithelial cilia. This phenomenon can be explained by the fact that an embryo developing in vivo is naturally exposed to constant vibrations of around 6Hz with the periodically repeating increase to 20Hz. This review covers the history of this question and in this light offers an explanation through biological concept for one of the most recent developments in this area: in-vitro culture of human embryos with mechanical micro-vibration. The effect of mechanical micro-vibration on embryos during their in-vitro culture was examined. Pregnancy rates after the transfer of embryos in the group with in-vitro culture under mechanical vibration were increased.

Copyright © 2011 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.
Reprod Biomed Online. 2011 Jun;22(6):536-44.


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