Wednesday, 10 January 2018 12:33
Published in IVF Research

“Naturalization” of Routine Assisted Reproductive Technologies by In Vitro Culture of Embryos with Microvibration: Sex Ratio, Body Length, and Weight of 2,456 Live-Birth Deliveries after Transfer of 9,624 Embryos In Vitro Cultured.

Vladimir Isachenko1; Karl Sterzik2; Evgenia Isachenko1; Robert Maettner2; Plamen Todorov3; Gohar Rahimi1; Peter Mallmann1; Erwin Strehler2; Igor Pereligin4; José Luis Alabart5; Markus Merzenich6

1 Research Group for Reproductive Medicine and IVF-Laboratory, Department of Obstetrics and Gynecology, Cologne University, Kerpener Str. 34, 50931 Cologne, Germany
2 Department of Reproductive Medicine, Christian-Lauritzen Institute, Frauenstr. 51, 89073 Ulm, Germany
3 Institute of Biology and Immunology of Reproduction, Tzarigradsko Shosse 73, 1113 Sofia, Bulgaria
4 IVF Center “Genesis Dnepr”, 119-120 Rybinska St., Dnipro, Ukraine
5 Servicio de Investigación Agroalimentaria (DGA), Avda. Montañana 930, 50059 Zaragoza, Spain
6 MedEvent Dr. Merzenich GmbH, Im Zollhafen 12, 50678 Cologne, Germany
 
* Address correspondence to Vladimir Isachenko, Dr.(SU), University Maternal Hospital, Department of Obstetrics and Gynecology, Cologne University, Kerpener Str. 34, 50931 Cologne, Germany Tel: +49-221-4784924; Fax: +49-221-4785247; E-mail:This email address is being protected from spambots. You need JavaScript enabled to view it.
Received 22 September 2017; Revised 13 November 2017; Accepted 5 December 2017; Published 20 December 2017
Academic Editor: Brad Upham
Copyright © 2017 Vladimir Isachenko et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract: Aim was to determine whether there is any difference in the sex ratio, body length, and body weight of 2,456 deliveries after transfer of 9,624 embryos derived using in vitro culture under static and mechanical microvibration conditions. Pronuclear embryos from 4435 patients were cultured in vitro under two different conditions: without () and with mechanical agitation (). Sex ratio, body length, and weight of 2,456 live-birth deliveries after transfer of 9,624 embryos were noted. The proportion of males at birth was significantly associated with mode of in vitro culture of embryos only among women aged 40 years and older. The rate “body length” was significantly associated with mode of in vitro culture of embryos only among women aged 29 and younger. In the same time, among twins, this ratio positively associated with in vitro culture of embryos under microvibration only among women aged 30–34 years as well as ≥40 years and negatively among women aged 35–39 years. It was concluded that birth weight of infants was positively associated with mode of in vitro culture of embryos under microvibration among women of all age groups. This trial registration number is ISRCTN13773904, registered 6 April 2016.

Key words: Baby-takehome rate; Embryonic cells transplantion; In vitro culture; Micro-vibration

BioMed Research International
Volume 2017 (2017), Article ID 4964053, 7 pages

Publisher: BioMed Research International

Volume 2017 (2017), Article ID 4964053, 7 pages

https://doi.org/10.1155/2017/4964053

 

Full text links: https://www.hindawi.com/journals/bmri/2017/4964053/

 
Last modified on Wednesday, 10 January 2018 12:52

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