Sunday, 01 March 2015 11:32
Published in IVF Research

Effect of micro-vibration culture system on embryo development

Hur YS1, Park JH, Ryu EK, Park SJ, Lee JH, Lee SH, Yoon J, Yoon SH, Hur CY, Lee WD, Lim JH

1 Department of Anatomy, School of Medicine, Kangwon National University, Chuncheon, 200-701, Korea
* Corresponding author. E-mail address: This email address is being protected from spambots. You need JavaScript enabled to view it.

Abstract

PURPOSE:
Micro-vibration culture system was examined to determine the effects on mouse and human embryo development and possible improvement of clinical outcomes in poor responders.

MATERIALS AND METHODS:
The embryonic development rates and cell numbers of blastocysts were compared between a static culture group (n = 178) and a micro-vibration culture group (n = 181) in mice. The embryonic development rates and clinical results were compared between a static culture group (n = 159 cycles) and a micro-vibration culture group (n = 166 cycles) in poor responders. A micro-vibrator was set at a frequency of 42 Hz, 5 s/60 min duration for mouse and human embryo development.

RESULTS:
The embryonic development rate was significantly improved in the micro-vibration culture group in mice (p < 0.05). The cell numbers of mouse blastocysts were significantly higher in the micro-vibration group than in the static culture group (p < 0.05). In the poor responders, the rate of high grade embryos was not significantly improved in the micro-vibration culture group on day 3. However, the optimal embryonic development rate on day 5 was improved in the micro-vibration group, and the total pregnancy rate and implantation rate were significantly higher in the micro-vibration group than in the static culture group (p < 0.05).

CONCLUSIONS:
Micro-vibration culture methods have a beneficial effect on embryonic development in mouse embryos. In poor responders, the embryo development rate was improved to a limited extent under the micro-vibration culture conditions, but the clinical results were significantly improved.

J Assist Reprod Genet. 2013 Jun;30(6):835-41.

Download:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3696450/pdf/10815_2013_Article_7.pdf

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