Evidence-based
Get access to relevant scientific, clinical papers evidencing the benefits of VIBOVIDUCT® technology.
“Naturalization” of Routine Assisted Reproductive Technologies by In Vitro Culture of Embryos with Microvibration: Sex Ratio, Body Length, and Weight of 2,456 Live-Birth Deliveries after Transfer of 9,624 Embryos In Vitro Cultured.
Vladimir Isachenko1; Karl Sterzik2; Evgenia Isachenko1; Robert Maettner2; Plamen Todorov3; Gohar Rahimi1; Peter Mallmann1; Erwin Strehler2; Igor Pereligin4; José Luis Alabart5; Markus Merzenich6
Research Group for Reproductive Medicine and IVF-Laboratory, Department of Obstetrics and Gynecology, Cologne University, Kerpener Str. 34, 50931 Co...
In vitro Micro-Vibration Increases Implantation Rate after Embryonic Cell Transplantation
Vladimir Isachenko1; Karl Sterzik2; Robert Maettner2; Evgenia Isachenko1; Plamen Todorov3; Gohar Rahimi1; Peter Mallmann1; Erwin Strehler2; Igor Pereligin4; José Luis Alabart5; Markus Merzenich6
1 University Maternal Hospital, Department of Obstetrics and Gynecology, Cologne University, Cologne, Germany 2 Department of Reproductive Medicine, ...
Novel culture platforms offer a pathway towards improving embryo development beyond the optimization of media composition, volume, and embryo spacing
Rethinking In Vitro Embryo Culture: New Developments in Culture Platforms and Potential to Improve Assisted Reproductive Technologies1
Gary D. Smith, Shuichi Takayama, Jason E. Swain
1. Research in the authors' laboratories (G.D.S. and S.T.) on culture platforms have been supported by the National Institutes of Health (NIH; HD 049607), the...
Micro-vibration culture of human embryos improves pregnancy and implantation rates
I. El-Danasouri, N.L. Sandi-Monroy, T. Winkle, K. Ott, C. Krebs, D.H.A. Maas, F. Gagsteiger
Kinderwunsch-Zentrum Ulm/ Stuttgart, Ulm, BW, Germany
* Corresponding author. E-mail address: This email address is being protected from spambots. You need JavaScript enabled to view it.
OBJECTIVE
Embryos in vivo are not present in a static condition, since in the fallopian tube they are exposed to continuous move...
Regular mechanical agitation during in vitro culture of human pre-implantation embryos has shown to drastically increase the respective development rate
Mechanical agitation during the in vitro culture of human pre-implantation embryos drastically increases the pregnancy rate
Evgenia Isachenko 1, Robert Maettner, Vladimir Isachenko, Steffen Roth, Rolf Kreienberg, Karl Sterzik
1. Section of Gynaecological Endocrinology and Reproductive Medicine, University of Ulm, Germany. e.isac...
Micro vibration culture methods have shown to have a beneficial effect on embryonic development in mouse embryos
Effect of micro-vibration culture system on embryo development
Yong Soo Hur 1, Jeong Hyun Park, Eun Kyung Ryu, Sung Jin Park, Jun Ho Lee, Soo Hee Lee, Jung Yoon, San Hyun Yoon, Chang Young Hur, Won Don Lee, Jin Ho Lim
1. Department of Anatomy, School of Medicine, Kangwon National University, Chuncheon, 200-701, Korea. geaher@...
Three-dimensional micro-vibration culture of oocytes and embryos may mimic the embryo’s in vivo environment and significantly increases implantation and pregnancy rates
Micro-vibration culture of human embryos improves pregnancy and implantation rates
I. El-Danasouri, N.L. Sandi-Monroy, T. Winkle, K. Ott, C. Krebs, D.H.A. Maas, F. Gagsteiger
Kinderwunsch-Zentrum Ulm/ Stuttgart, Ulm, BW, Germany
* Corresponding author. E-mail address: This email address is being protected from spambots. You need JavaScript enabled to view it.
OBJECTIVE
Embryos in vivo are not presen...
Micro vibration and group culturing increase fertilization and implantation rates in human embryos
Micro-Vibration culture and group culture increase fertilization and implantation rates in human embryos
El Danasouri 1, N. Sandi-Monroy, T. Winkle, N. Reeka, F. Gagsteiger
1 Kinderwunschzentrum Ulm, Praxis Dr. Gagsteiger, Ulm, Germany
* Corresponding author. E-mail address: This email address is being protected from spambots. You need JavaScript enabled to view it.
Abstract Several...
Clinical pregnancy rate can be significantly increased by the application of micro-vibration to the embryonic cultures of poor responders. Moroever, the blastocyst development rate can significantly be increased by the application of MCoC to surplus embry
Comparison of static culture, micro-vibration culture, and micro-vibration culture with co-culture in poor ovarian responders
Yong Soo Hur1, Eun Kyung Ryu1, San Hyun Yoon2, Kyung Sil Lim1, Won Don Lee1, Jin Ho Lim1
1. Maria Fertility Hospital, Seoul, Korea
2. Maria Fertility Research Center, Seoul, Korea.
Corresponding autho...
In vitro culture of human embryos in a medium subjected to regular short intervals of mechanical agitation leads to increased development rates.
In-vitro culture of human embryos with mechanical micro-vibration increases implantation rates
Vladimir Isachenko 1, Robert Maettner, Karl Sterzik, Erwin Strehler, Rolf Kreinberg, Katharina Hancke, Steffen Roth, Evgenia Isachenko
1. Section of Gynaecological Endocrinology and Reproductive Medicine, University of Ulm, Prittwit...
Optimization of the in vitro environment involves far more than improving culture media formulations. Physical factors play a pivotal role.
The effects of chemical and physical factors on mammalian embryo culture and their importance for the practice of assisted human reproduction
Petra L Wale 1, David K Gardner 2
1. School of BioSciences, University of Melbourne, Parkville, Victoria, Australia Melbourne IVF, Melbourne, Victoria, Australia This email address is being protected from spambots. You need JavaScript enabled to view it.
2. Sc...
The initiation of embryo development depends on a Ca2+ increase in the egg, which is generally induced during fertilization
Ca2+ signaling during mammalian fertilization: requirements, players, and adaptations
Takuya Wakai 1, Veerle Vanderheyden, Rafael A Fissore
1. Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, Massachusetts 01003, USA
Cold Spring Harb Perspect Biol. 2011 Apr 1;3(4):a006767 d...
Mechanical in vitro stimulation of epithelial cells induces a wave of increasing Ca2+ that spreads, cell by cell, from stimulated to neighboring cells
Mechanical stimulation and intercellular communication increases intracellular Ca2+ in epithelial cells
M J Sanderson 1, A C Charles, E R Dirksen
1. Department of Anatomy and Cell Biology, School of Medicine, University of California, Los Angeles 90024.
Sanderson et al., Cell Regul. 1990 Jul;1(8):585-96...
The ability to mount and respond to an appropriate Ca2+ signal at fertilisation is largely unchanged by advancing maternal age, but subtle changes in Ca2+ handling occur that may have more substantial impacts upon commonly used means of parthenogenetic ac
Ca2+ dynamics in oocytes from naturally-aged mice
Jenna Haverfield1, Shoma Nakagawa1, Daniel Love2, Elina Tsichlaki3, Michail Nomikos2, F. Anthony Lai2, Karl Swann2 & Greg FitzHarris1,3
Centre Recherche Centre Hospitalier Université de Montréal, Montreal, Québec, H2X 0A9, CanadA, Department of Obstetrics and Gynaecology, University of...
In vitro culture of embryos under microvibration (mimicking conditions in nature whereby oviductal fluid is mechanically agitated by the epithelial cilia) significantly increases the baby take-home rate for patients 30 years of age and older.
In vitro Micro-Vibration Increases Implantation Rate after Embryonic Cell Transplantation
Vladimir Isachenko1; Karl Sterzik2; Robert Maettner2; Evgenia Isachenko1; Plamen Todorov3; Gohar Rahimi1; Peter Mallmann1; Erwin Strehler2; Igor Pereligin4; José Luis Alabart5; Markus Merzenich6
1 University Maternal Hospital, Department of Obstet...
Birth weight of infants is positively associated with the mode of in vitro culture of embryos under microvibration among women of all age groups.
“Naturalization” of Routine Assisted Reproductive Technologies by In Vitro Culture of Embryos with Microvibration: Sex Ratio, Body Length, and Weight of 2,456 Live-Birth Deliveries after Transfer of 9,624 Embryos In Vitro Cultured in Static System and with Microvibration
Vladimir Isachenko,1 Karl Sterzik,2 Evgenia Isachenko,1 Robert Maettner...